Anti-Thrombin Deficiency (Last Updated - 2/25/2005)
1) Acquired:
-pts. have only ~25% of normal anti-thrombin levels (vs. 40%-60% in Inherited Anti-Thrombin Deficiency)
-requires increased IV Heparin dosing to achieve usual aPTT increases
-seen with:
1) Hepatic Cirrhosis
2) Nephrotic Syndrome
3) DIC
vs.
2) Inherited:
-pts. have only ~40%-60% of normal anti-thrombin levels (vs. 25% in Acquired Anti-Thrombin Deficiency)
-pts. should respond normally to IV Heparin dosing
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References:
Goodman & Gilman's: The Pharmacologic Basis Of Therapeutics - 10th Edition - 2001. Chapter 55.